Our Materials : Triad Life Sciences

What We Do

Triad utilizes placental technologies to design a product portfolio capable of treating a wide array of wounds and injuries.

The Extracellular Matrix (ECM) derived from biological structures such as the placenta, “serves as a reservoir for biochemical and biophysical signals to support cell survival, organization, and differentiation”³and plays a critical role in healthy fetal development and protection.² It is a naturally immune-privileged,¹ bio-compatible¹structure that when collected, processed, and preserved, may provide the ideal material utilized for wound care.^{1, 3}

There are several potential advantages of utilizing the amniotic tissue for wound care, including:

Acts as a protective barrier for the wound, which promotes uninterrupted healing^2,³
Contains growth factors that may recruit the patient’s local cells to migrate to the site, proliferate, and even differentiate^2,3,4
May support Angiogenesis, as VEGF is one specific growth factor that is known to be associated with stimulating the formation of new blood vessels to support regenerative activity^2,³
Reduces potential for scarring and inflammation^1,3,4

Engineered by Nature

The Amniotic Tissue is composed of three critical components: Growth Factors & Cytokines, TIMPs & Interleukins, and a Collagen Scaffold.^1,4 These three components are equally important and interact with each other and the site throughout the healing process.

References

1: Hortensius, Rebecca A, and Brendan AC Harley. “Naturally Derived Biomaterials for Addressing Inflammation in Tissue Regeneration.” Experimental Biology and Medicine, vol. 241, 2016, pp. 1015–1024., doi: 10.1177/1535370216648022.

2: Klama-Baryła, A., et al. “Experience in Using Fetal Membranes: The Present and New Perspectives.” Transplantation Proceedings, vol. 50, no. 7, 2018, pp. 2188–2194., doi:10.1016/j.transproceed.2018.02.120.

3: Hussey, George S., et al. “Extracellular Matrix-Based Materials for Regenerative Medicine.” Nature Reviews Materials, vol. 3, no. 7, 29 July 2018, pp. 159–166., doi:10.1038/s41578-018-0023-x.

4: Schultz, Gregory S., et al. “Dynamic Reciprocity in the Wound Microenvironment.” Wound Repair and Regeneration, vol. 19, no. 2, Mar. 2011, pp. 134–148., doi:10.1111/j.1524-475x.2011.00673.x.